Blockchain Press Releases
Rznomics Presents Its Own Circular RNA Platform Technology
SEONGNAM, South Korea, Aug. 3, 2023 /PRNewswire/ — Rznomics developed a novel platform technology termed ‘self-circularized RNA structure’ that can efficiently and simply generate circular RNA and overcome the limitations of existing technology. Rznomics published an article regarding its development strategy and efficacy in the journal ‘Molecular Therapy Nucleic Acids.’
Since the success of the COVID-19 vaccine, mRNA technology has been studied with great interest in various fields, such as vaccines and therapeutics. However, conventional linear mRNA is vulnerable to nucleases, and patent-protected modified nucleic acids need to be used for efficient protein expression with the reduction of unwanted immune responses.
To overcome the drawbacks of the conventional linear RNAs mentioned above, circular RNA structure technology has recently attracted attention. Circular RNA (circRNA) has a closed structure, so it has great stability against nucleases, and it has been reported that there are no influences on unwanted immune responses and protein expression without using the modified nucleotides. Therefore, if it is commercialized, circRNA vaccines or therapeutics will potentially be more competitive in price and will have the same efficacy equivalent to linear RNA in a smaller amount.
Attracting large-scale investments, a couple of major biotech companies in the U.S. lead the circRNA R&D industry and show the expectations from the market. In the case of one of these companies, they use a circRNA manufacturing technology based on group I intron ribozyme, called the Permuted Intron-Exon (PIE) method. The PIE method splits the ribozyme, which was used in the cis-splicing reaction to remove the intron and link the flanking exons, into half and connects each half of ribozyme to both ends of the GOI (Gene of interest) to make the circRNA with specific GOI. Since the immaturity stage of the circRNA field, there are rooms for biotech companies to enter the competition. However, to enter the market with competitiveness, the core & innovative platform technology that overcomes the limitations of existing technologies is essential.
Rznomics has developed a new circular RNA manufacturing technology that uses group I intron ribozyme as well. However, the technology is fundamentally different from the PIE method in the circularization mechanism. Rznomics has recently published its own circular RNA technology on line in Molecular Therapy Nucleic Acids (DOI: https://doi.org/10.1016/j.omtn.2023.07.034, Title; Efficient circular RNA engineering by end-to-end self-targeting and splicing reaction using Tetrahymena ribozyme), the official journal of the American Society for Gene and Cell Therapy (ASGCT). Rznomics applied its unique Tetrahymena trans-splicing ribozyme platform technology to effectively convert linear RNA into circular RNA by designing end-to-end self-targeting and splicing (STS) reaction.
As shown in the figure, an RNA construct was designed to connect the GOI at the end of the group I intron ribozyme. In this construct, the target site that can be targeted by ribozyme and IGS (Internal Guide Sequence) that guides the targeted trans-ligation by base-pairing with the target site were designed to locate at both ends to enable the circular RNA formation through a self-circularization reaction.
The most notable point is that in contrast to the PIE method, Rznomics’ circularization technology does not leave traces of non-necessary genetic information in the GOI (Gene of Interest) after the self-circularization reaction. In the case of PIE, the ribozyme needs to connect both ends of the GOI harboring extraneous specific nucleotide sequences to form a circular RNA. Whereas, in the case of STS reaction, the ribozyme leads to self-circularization by designing any target sequence present in GOI to be located at the end of GOI.
Also, Rznomics confirmed that circularization efficiency is comparable to the efficiency of the PIE method. In addition, due to the nature of the STS reaction, it is possible to establish various optimization strategies to increase the self-circularization efficiency, unlike the PIE method. It is considered that the self-circularization efficiency decreases as the length of the gene of interest. However, in the case of Rznomics technology, it is possible to screen an optimal target sequence that maximizes the efficacy of self-circularization. Rznomics stated that, through the STS-based reaction, long RNA such as human dystrophin RNA (11,265 nucleotides) was successfully self-circularized.
Moreover, a self-circularization reaction occurs simultaneously during in vitro transcription which is the process of synthesizing RNA. Therefore, the purification process can be directly initiated without any additional steps of the process. In the published paper, Rznomics also mentioned a method for purifying the circRNA using the IP-RP HPLC technique. The purified circRNA with unmodified nucleotides enabled more efficient and sustained protein expression without unwanted immune responses, compared with linear RNA with modified nucleotides.
This research was conducted with the support of the Ministry of Science & ICT and the National Research Foundation of Korea. The ‘Self-circularization RNA structure and Platform technology’ is a patent granted in South Korea (10-2442946) and has been applied in the U.S. and major countries.
About Rznomics
As a biopharmaceutical company founded in the laboratory of Professor Seong-Wook Lee, Dankook University Department of Bioconvergence Engineering, Rznomics is researching with the goal of developing new RNA-based gene therapeutic bio-drugs for cancer and incurable diseases. Rznomics’ core platform technology is based on an RNA replacement enzyme, known as trans-splicing ribozyme, which can edit target RNA through simultaneous destruction and repair (and/or reprogramming) to yield the desired therapeutic RNA, thus, selectively inducing therapeutic gene activity in cells expressing the target RNA.
Rznomics’ lead candidate (RZ-001) is a treatment for Hepatocellular Carcinoma & Glioblastoma (Phase 1/2a IND approval from both in South Korea and in the U.S.), with other treatments for Alzheimer’s disease and hereditary retinal dystrophy (RD). For more information, please visit www.rznomics.com.
Contact
[email protected]
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Blockchain Press Releases
Markets Show Resilience Ahead of End-of-Year Options Expirations: Bybit x Block Scholes Crypto Derivatives Report
DUBAI, UAE, Dec. 26, 2024 /PRNewswire/ — Bybit, the world’s second-largest cryptocurrency exchange by trading volume, released the latest Crypto Derivatives Analytics Report in collaboration with Block Scholes, highlighting the muted market volatility despite major options expirations on Friday. BTC and ETH’s realized volatility has increased, but short-term options haven’t adjusted to this change. This indicates that while spot prices are fluctuating, the options market is not fully reacting to these shifts, although BTC and ETH volumes have displayed slightly different patterns.
With more than $525 million in BTC and ETH options contracts expiring on Dec 27, 2024’s end-of-year options expiration looks set to be one of the biggest yet, yet expectations for volatility have remained subdued. The report highlights an unusual inversion in ETH’s volatility structure, but BTC has not mirrored the reaction. Additionally, a change in funding rates—sometimes turning negative as spot prices drop—signals a new market phase. Notably, BTC’s volatility structure has been less responsive to changes in spot prices, whereas ETH’s short-term options are exhibiting more noticeable fluctuations.
Key Findings:
BTC Options Expirations:
In the past month, BTC’s realized volatility has been higher than implied volatility on three occasions, each time reaching a relatively calm equilibrium. Open interest in BTC options remains high, contributing to potential increased volatility as we near the end of the year. Around $360 million worth of BTC options (both puts and calls) are set to expire soon, which can affect price movement.
ETH Options: Calls Dominate
Despite a mid-week inversion, ETH’s volatility term structure has flattened, maintaining levels similar to those seen over the past month. In the final week of 2024, calls overwhelmed puts in open interest in ETH options, although market movements and trading activities are more on the put side.
Access the Full Report:
Gain deeper insights and explore the potential impacts on your crypto trading strategies by downloading the full report here: Bybit X Block Scholes Crypto Derivatives Analytics Report (Dec 24, 2024)
#Bybit / #BybitResearch
About Bybit
Bybit is the world’s second-largest cryptocurrency exchange by trading volume, serving a global community of over 60 million users. Founded in 2018, Bybit is redefining openness in the decentralized world by creating a simpler, open and equal ecosystem for everyone. With a strong focus on Web3, Bybit partners strategically with leading blockchain protocols to provide robust infrastructure and drive on-chain innovation. Renowned for its secure custody, diverse marketplaces, intuitive user experience, and advanced blockchain tools, Bybit bridges the gap between TradFi and DeFi, empowering builders, creators, and enthusiasts to unlock the full potential of Web3. Discover the future of decentralized finance at Bybit.com.
For media inquiries, please contact: [email protected]
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NICOSIA, Cyprus, Dec. 26, 2024 /PRNewswire/ — BC.GAME has launched its latest slot game, Wukong, inspired by the highly acclaimed Black Myth: Wukong, a groundbreaking AAA game that has captivated players worldwide. Officially released on December 24, this 6-reel, 5-row slot game allows players to experience the essence of Wukong’s legendary journey while aiming for rewards of up to 10,000 times their bet.
The game incorporates iconic symbols and elements from Black Myth: Wukong, such as the Ruyi staff, gourd bottles, and treasure pearls, designed to recreate the mythical atmosphere of the original story. The addition of the Sticky Symbols feature enhances gameplay by keeping special symbols locked in place during free spins, significantly increasing the chances of winning and unlocking larger rewards.
Dark Visual Design and Storytelling Behind Wukong
The visual design of Wukong draws from traditional Chinese art styles, blending elements from Journey to the West. The reels are filled with recognizable symbols like the Ruyi staff, gourd bottles, and treasure pearls. These symbols immerse players in the mythical world of the story, faithfully recreating key moments from the novel, such as Sun Wukong’s havoc in Heaven and his encounters with the White Bone Demon.
The game’s background is rooted in Journey to the West, where Sun Wukong embarks on a journey with the monk Tang Seng and his companions to obtain sacred scriptures. Each detail of the game is carefully crafted to bring this legendary tale to life, offering a unique gaming experience and a tribute to Chinese culture and mythology.
Key Features of the Wukong Slot Game:
Free Spins and Bonus Opportunities: Triggering free spins unlocks additional reward mechanisms, increasing the chances of landing big wins.
Sticky Symbols Feature: Special symbols remain in place during free spins, greatly enhancing winning potential.
Up to 10,000x Max Win: The game offers a maximum payout of up to 10,000 times the bet, providing significant winning opportunities.
“Wukong is not just about spinning reels; it’s about experiencing a rich part of Chinese culture. We’ve worked hard to ensure the game is stunning and fun and engaging for players, with layers of features that add excitement. We’re proud to offer a game that blends storytelling with gameplay, and we think players will love the journey through Wukong’s legendary world,” Jack Dorset, CEO of BC.GAME said.
About BC.GAME
BC.GAME is a leading online gaming platform that integrates blockchain technology and cryptocurrency into its casino games, by offering a secure, transparent, and decentralized experience, BC.GAME allows players to enjoy a variety of gaming options, including slots, table games, and live casino offerings. The platform is dedicated to providing players with exciting, fair, and innovative ways to engage with the world of gaming. citing, fair, and innovative ways to engage with the world of gaming.
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Blockchain Press Releases
WSPN Appoints Former EY Global Chief Innovation Officer Jeff Wong as Independent Director
SINGAPORE, Dec. 26, 2024 /PRNewswire/ — Worldwide Stablecoin Payment Network (WSPN), a leading stablecoin infrastructure company, announces the appointment of Jeff Wong as Independent Director. Mr. Wong brings over 25 years of experience in technology innovation and enterprise transformation to WSPN. He most recently served as EY’s Global Chief Innovation Officer from 2015 to 2024, where he spearheaded the firm’s global innovation initiatives and established EY’s advanced technology labs focusing on Artificial Intelligence, Blockchain, Quantum Computing, and Web3.
Prior to EY, Mr. Wong held leadership roles at eBay and JPMorgan Partners. He is a member of the Council on Foreign Relations, the Forbes Technology Council, and the founding Chair of Asia Society’s Technology and Innovation Council, helping drive the innovation and transformation agenda. He was also a member of the World Economic Forum’s Global Future Council on Innovation Ecosystems. He has previously served on the Oxford Foundry Board at Oxford University and the Advisory Board for AI4All. Mr. Wong is a recipient of the Outstanding 50 Asian Americans in Business award and an honoree of the A100 List by Gold House, recognizing individuals with Asian Pacific heritage who have made a significant impact on American culture and society.
“Joining WSPN at this pivotal moment in the stablecoin industry is incredibly exciting,” said Mr. Wong. “I look forward to contributing my experience in emerging technologies and enterprise transformation to help WSPN build the next generation of digital payment infrastructure.”
“Jeff’s appointment represents a significant strategic addition to WSPN,” said Raymond Yuan, Founder and CEO of WSPN. “His deep expertise in innovation management, enterprise transformation, and emerging technologies, combined with his leadership experience at global institutions, will be invaluable as we accelerate our market expansion and global development.”
About WSPN
WSPN is a leading provider of next-generation stablecoin infrastructure, committed to building a more secure, efficient, and transparent payment solution for the global economy. Their flagship product, WUSD stablecoin, is pegged 1:1 to the U.S. Dollar and aims to optimize secure digital payments for Web3 users. WSPN’s Stablecoin 2.0 approach prioritizes user-centricity, community governance, and accessibility, paving the way for widespread stablecoin adoption.
Learn more: www.wspn.io | X | LinkedIn
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