Blockchain Press Releases
Rznomics Presents Its Own Circular RNA Platform Technology
SEONGNAM, South Korea, Aug. 3, 2023 /PRNewswire/ — Rznomics developed a novel platform technology termed ‘self-circularized RNA structure’ that can efficiently and simply generate circular RNA and overcome the limitations of existing technology. Rznomics published an article regarding its development strategy and efficacy in the journal ‘Molecular Therapy Nucleic Acids.’
Since the success of the COVID-19 vaccine, mRNA technology has been studied with great interest in various fields, such as vaccines and therapeutics. However, conventional linear mRNA is vulnerable to nucleases, and patent-protected modified nucleic acids need to be used for efficient protein expression with the reduction of unwanted immune responses.
To overcome the drawbacks of the conventional linear RNAs mentioned above, circular RNA structure technology has recently attracted attention. Circular RNA (circRNA) has a closed structure, so it has great stability against nucleases, and it has been reported that there are no influences on unwanted immune responses and protein expression without using the modified nucleotides. Therefore, if it is commercialized, circRNA vaccines or therapeutics will potentially be more competitive in price and will have the same efficacy equivalent to linear RNA in a smaller amount.
Attracting large-scale investments, a couple of major biotech companies in the U.S. lead the circRNA R&D industry and show the expectations from the market. In the case of one of these companies, they use a circRNA manufacturing technology based on group I intron ribozyme, called the Permuted Intron-Exon (PIE) method. The PIE method splits the ribozyme, which was used in the cis-splicing reaction to remove the intron and link the flanking exons, into half and connects each half of ribozyme to both ends of the GOI (Gene of interest) to make the circRNA with specific GOI. Since the immaturity stage of the circRNA field, there are rooms for biotech companies to enter the competition. However, to enter the market with competitiveness, the core & innovative platform technology that overcomes the limitations of existing technologies is essential.
Rznomics has developed a new circular RNA manufacturing technology that uses group I intron ribozyme as well. However, the technology is fundamentally different from the PIE method in the circularization mechanism. Rznomics has recently published its own circular RNA technology on line in Molecular Therapy Nucleic Acids (DOI: https://doi.org/10.1016/j.omtn.2023.07.034, Title; Efficient circular RNA engineering by end-to-end self-targeting and splicing reaction using Tetrahymena ribozyme), the official journal of the American Society for Gene and Cell Therapy (ASGCT). Rznomics applied its unique Tetrahymena trans-splicing ribozyme platform technology to effectively convert linear RNA into circular RNA by designing end-to-end self-targeting and splicing (STS) reaction.
As shown in the figure, an RNA construct was designed to connect the GOI at the end of the group I intron ribozyme. In this construct, the target site that can be targeted by ribozyme and IGS (Internal Guide Sequence) that guides the targeted trans-ligation by base-pairing with the target site were designed to locate at both ends to enable the circular RNA formation through a self-circularization reaction.
The most notable point is that in contrast to the PIE method, Rznomics’ circularization technology does not leave traces of non-necessary genetic information in the GOI (Gene of Interest) after the self-circularization reaction. In the case of PIE, the ribozyme needs to connect both ends of the GOI harboring extraneous specific nucleotide sequences to form a circular RNA. Whereas, in the case of STS reaction, the ribozyme leads to self-circularization by designing any target sequence present in GOI to be located at the end of GOI.
Also, Rznomics confirmed that circularization efficiency is comparable to the efficiency of the PIE method. In addition, due to the nature of the STS reaction, it is possible to establish various optimization strategies to increase the self-circularization efficiency, unlike the PIE method. It is considered that the self-circularization efficiency decreases as the length of the gene of interest. However, in the case of Rznomics technology, it is possible to screen an optimal target sequence that maximizes the efficacy of self-circularization. Rznomics stated that, through the STS-based reaction, long RNA such as human dystrophin RNA (11,265 nucleotides) was successfully self-circularized.
Moreover, a self-circularization reaction occurs simultaneously during in vitro transcription which is the process of synthesizing RNA. Therefore, the purification process can be directly initiated without any additional steps of the process. In the published paper, Rznomics also mentioned a method for purifying the circRNA using the IP-RP HPLC technique. The purified circRNA with unmodified nucleotides enabled more efficient and sustained protein expression without unwanted immune responses, compared with linear RNA with modified nucleotides.
This research was conducted with the support of the Ministry of Science & ICT and the National Research Foundation of Korea. The ‘Self-circularization RNA structure and Platform technology’ is a patent granted in South Korea (10-2442946) and has been applied in the U.S. and major countries.
About Rznomics
As a biopharmaceutical company founded in the laboratory of Professor Seong-Wook Lee, Dankook University Department of Bioconvergence Engineering, Rznomics is researching with the goal of developing new RNA-based gene therapeutic bio-drugs for cancer and incurable diseases. Rznomics’ core platform technology is based on an RNA replacement enzyme, known as trans-splicing ribozyme, which can edit target RNA through simultaneous destruction and repair (and/or reprogramming) to yield the desired therapeutic RNA, thus, selectively inducing therapeutic gene activity in cells expressing the target RNA.
Rznomics’ lead candidate (RZ-001) is a treatment for Hepatocellular Carcinoma & Glioblastoma (Phase 1/2a IND approval from both in South Korea and in the U.S.), with other treatments for Alzheimer’s disease and hereditary retinal dystrophy (RD). For more information, please visit www.rznomics.com.
Contact
[email protected]
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PANAMA CITY, April 22, 2025 /PRNewswire/ — BingX, a global leading cryptocurrency exchange, kicks off its 7th anniversary as a Platinum Sponsor at TOKEN2049 Dubai. This premier Web3 gathering marks the beginning of a global series of festivities commemorating BingX’s milestone. As the anniversary unfolds, BingX will continue its celebration with a lineup of offline events around the world, uniting users, partners, and communities in a shared journey of growth and gratitude.
Attendees at the TOKEN2049 conference will be able to enjoy the vibrant anniversary spirit that infuses the event experience. The celebratory atmosphere, from immersive booth interactions to BingX-branded boats adorning the waterfront, highlights the connections BingX has built with its global user base. Attendees will also have the opportunity to meet BingX’s core team, provide feedback, and discover the strategy and innovation behind the platform’s latest product developments. In addition, BingX will host a private side event, bringing together key partners, traders, and community members for a meaningful evening of connection and reflection.
“We are proud to mark our 7th anniversary with meaningful moments alongside our global community,” said Vivien Lin, Chief Product Officer of BingX. “Dubai is one of the many ideal places to celebrate how far we’ve come — not just as a platform, but as a user-first brand. From our early days to now being a top 5 derivative platform, our journey has been shaped by every user, every conversation, and the stories they tell. By showing up at TOKEN2049 as a major sponsor, we are reinforcing our belief that innovation starts with us listening.”
BingX’s celebration is already well underway. The “Your Voice, Our Story” Campaign invited users to share their personal journeys with BingX, shining a light on the very community that helped shape the platform. Chelsea FC and BingX also teamed up to launch the Bitcoin Fantasy 7 campaign, giving fans the chance to build their dream team and win exclusive prizes. Coming up next is a global trading campaign featuring various competitions, community rewards, and special giveaways as well. Together, activities reflect BingX’s commitment to creating fun, rewarding experiences that strengthen its connection with users worldwide
About BingX
Founded in 2018, BingX is a leading crypto exchange, serving over 20 million users worldwide. BingX offers diversified products and services, including spot, derivatives, copy trading, and asset management – all designed for the evolving needs of users, from beginners to professionals. BingX is committed to providing a trustworthy platform that empowers users with innovative tools and features to elevate their trading proficiency. In 2024, BingX proudly became the official crypto exchange partner of Chelsea Football Club, marking an exciting debut in the world of sports.
For more information please visit: https://bingx.com/
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Blockchain Press Releases
MEXC Exchange Report Shows Airdrops Resulting in Up to 35% New User Registrations
VICTORIA, Seychelles, April 22, 2025 /PRNewswire/ — A report released by MEXC, a leading global crypto exchange, indicates that airdrop campaigns account for approximately one-third of new user registrations during peak months. The numbers showcase the effectiveness of airdrops as a marketing instrument that crypto projects can leverage to attract new audiences and bootstrap engagement. The report also highlights the importance of ongoing structural shifts taking place in the industry across regions, as well as user motivation swings.
Key Takeaways:
- Peak user acquisition rates driven by airdrops reach up to 35% in certain months.
- User behavior is influencing airdrop campaign participation through deeper mobile penetration and the involvement of gamification mechanisms.
- 76% of users who sign up via airdrop campaigns remain on the platform, with 18% becoming active traders and 58% trading occasionally.
- The CIS region leads in terms of involvement at 67%, followed by Southeast Asia at 51%, and South Asia at 32%.
- Airdrops are evolving into a means of financial inclusion, in addition to acting as an effective marketing instrument.
MEXC analyzed user behavior during airdrop campaigns and identified a significant shift in the audience. While regions with low levels of access to banking services previously served as the main source of airdrop participants, the latest report indicates that new channels of user onboarding are ousting the trend. Gamification and Tap-to-Earn games in mobile-based Telegram channels are taking center stage as key registration sources for users with no previous experience in crypto. For instance, games like Hamster Kombat attracted over 70 million users, other notable examples of similar grade being Notcoin and Yescoin.
According to the data compiled as a result of the research, users who received their first airdrop tokens demonstrated varying degrees of continued involvement in the crypto industry. As many as 18% maintained active trading patterns and delved deeper into crypto services, 58% traded occasionally, while 24% were one-off users, withdrawing their funds without further engagement in trading. The users who evolve into active traders showcase an average daily trading volume above $58,000, with select ones achieving $31 million.
Regional segmentation of the users attracted via airdrops shows that the CIS is in a leading position, with 67% of the total, followed by Southeast Asia at 51%, and South Asia with 32%. The results of the analysis correlate with low levels of access to banking services in the given regions. They also align with data provided by Chainalysis, which positioned India, Vietnam, and the Philippines as the countries in Asia with the highest rates of crypto adoption, driven by low levels of banking services access and rapid spread of internet coverage in rural areas.
The limited financial inclusion of the countries in the indicated regions into the international banking system paves the way for cryptocurrencies to act as alternative means of payment both abroad and within domestic economies. Users participating in airdrops either withdraw them to fiat or use them for their needs. Pakistan and the Philippines are leading in this regard.
The report released by MEXC highlights the prominent role airdrops are occupying in the evolving crypto landscape, transforming from a marketing action into a separate instrument for user engagement. The ability to attract 35% new user registrations via airdrops in select regions like the CIS and Asia is a powerful factor acting in favor of using the given approach to expanding the crypto industry and advancing its maturity.
About MEXC
Founded in 2018, MEXC is committed to being “Your Easiest Way to Crypto.” Serving over 36 million users across 170+ countries, MEXC is known for its broad selection of trending tokens, everyday airdrop opportunities, and low trading fees. Our user-friendly platform is designed to support both new traders and experienced investors, offering secure and efficient access to digital assets. MEXC prioritizes simplicity and innovation, making crypto trading more accessible and rewarding.
For more information, visit: MEXC Official Website | X | Telegram | How to Sign Up on MEXC
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Blockchain Press Releases
MEXC Announces Listing of Hyperlane (HYPER) with a 165,000 HYPER and 50,000 USDT Prize Pool
VICTORIA, Seychelles, April 21, 2025 /PRNewswire/ — MEXC, a leading global cryptocurrency exchange, announced the Hyperlane (HYPER) listing on April 22, 2025(UTC).To celebrate this significant addition to the exchange, MEXC is launching a special event with a prize pool of 165,000 HYPER and 50,000 USDT for new and existing users.
Hyperlane is the first permissionless, universal interoperability protocol dedicated to building a truly open and decentralized cross-chain communication infrastructure. As “The Open Interoperability Framework,” it enables anyone to freely expand, utilize, and customize the network, allowing developers to easily and securely build cross-chain applications and token bridges. To date, Hyperlane has connected over 140 blockchains, processed nearly 9 million cross-chain messages, and bridged more than $6 billion in volume through its Warp Routes.
$HYPER is the native token of the Hyperlane ecosystem, with an initial total supply of 1 billion tokens. It plays a critical role in securing the protocol through staking, rewarding validators for verifying cross-chain messages, incentivizing user-driven activity, and enabling community governance over protocol development.
To celebrate the listing, MEXC will launch an Airdrop+ event with substantial rewards for users:
Event Period: April 21, 2025, 10:00 – May 01, 2025, 10:00 (UTC)
Benefit 1: Deposit and share 120,000 HYPER (New user exclusive)
Benefit 2: Spot Challenge — Trade to share 15,000 HYPER (For all users)
Benefit 3: Futures Challenge — Trade to share 50,000 USDT in Futures bonus (For all users)
Benefit 4: Invite new users and share 30,000 HYPER (For all users)
MEXC has established itself as a leading exchange by consistently offering users early access to high-potential crypto assets. In 2024 alone, the platform listed 2,376 new tokens, including 1,716 initial listings. According to the latest TokenInsight report, MEXC led the industry with 461 spot listings between November 1, 2024, and February 15, 2025. During this period, the exchange maintained a high listing frequency, consistently ranking among the top six platforms, demonstrating its agility in capturing emerging market trends. MEXC will continue to expand its asset offerings and help users seize timely opportunities in the fast-moving crypto market.
For full event details and participation rules, please visit here.
About MEXC
Founded in 2018, MEXC is committed to being “Your Easiest Way to Crypto.” Serving over 36 million users across 170+ countries, MEXC is known for its broad selection of trending tokens, everyday airdrop opportunities, and low trading fees. Our user-friendly platform is designed to support both new traders and experienced investors, offering secure and efficient access to digital assets. MEXC prioritizes simplicity and innovation, making crypto trading more accessible and rewarding.
MEXC Official Website｜ X ｜ Telegram ｜How to Sign Up on MEXC
Risk Disclaimer:
The information provided in this article regarding cryptocurrencies does not constitute investment advice. Given the highly volatile nature of the cryptocurrency market, investors are encouraged to carefully assess market fluctuations, the fundamentals of projects, and potential financial risks before making any trading decisions.
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