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InSilicoTrials and Axoltis Pharma Collaborate to Advance Therapeutic Solutions for Neurological Disorders

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MILAN, July 27, 2023 /PRNewswire/ — InSilicoTrials, a leading provider of artificial intelligence (AI) and simulation tools for drug and medical device development, has embarked on a collaborative partnership with Axoltis Pharma, a biopharmaceutical company committed to developing disease-modifying drugs for patients with high unmet medical needs in neurodegenerative and traumatic neurologic impairments. This strategic collaboration works to revolutionize our understanding of Central Nervous System (CNS) diseases and to optimize the clinical development plan of Axoltis’ drug candidate, NX210c, a promising 12-amino acid peptide derived from SCO-spondin. 

 

The primary focus of this partnership is to utilize the InSilicoTrials’ platform and leverage its InSilicoNEURO suite, which encompasses a variety of mechanistic CNS models. More specifically, the models within InSilicoNEURO will be used to assess the impact of Axoltis’ drug candidate on virtual patients with different conditions, including Amyotrophic Lateral Sclerosis (ALS), Parkinson’s Disease and Multiple sclerosis (MS). Mechanistic CNS models are designed to simulate the physiological and pathological aspects of CNS disorders, providing insights into the disease mechanisms and potential therapeutic interventions. Integrating knowledge from various data sources, these models help researchers and clinicians understand the complex interactions within the CNS and contribute to the development of improved diagnostics and disease-modifying treatments for CNS disorders. 

Neurodegenerative conditions are often characterized by several common features, including blood-brain barrier leakage, synaptic transmission deteriorations, and neuron apoptosis. Given that Axoltis drug candidate NX210c targets these features, the collaboration with InSilicoTrials holds great promise for supporting CNS functions in a wide range of neurological and neurodegenerative conditions. By utilizing the InSilicoTrials’ digital platform and leveraging Phase Ib clinical trial data and the preclinical package, the collaboration works to assess the relationship between NX210c dosing regimens, blood brain barrier repair and neurological function, biomarker concentrations, and ultimately clinical efficacy and safety endpoints, through computational modeling and simulation (CM&S) and AI techniques

Unlocking the potential of artificial intelligence and computational modeling, the two companies work to accelerate research and development, minimize costs, and optimize time utilization.  

We are thrilled to collaborate with Axoltis in our shared mission to advance therapeutic solutions for neurological disorders,” said Luca Emili, CEO of InSilicoTrials. “This partnership represents an exciting synergy between cutting-edge simulation technologies and innovative biotechnological advancements. Together, we aim to unlock new insights and develop groundbreaking treatments that will positively impact the lives of patients with neurologic impairments worldwide.” 

Dr. Yann Godfrin, CEO of Axoltis stated: “We are very delighted to initiate this collaboration with InSilicoTrials and have the opportunity to optimize and accelerate our next clinical steps. Integrating their industry-leading AI and computational modeling solutions in the development plan of our promising disease-modifying drug will allow us to address the pressing challenges faced by individuals suffering from neurological disorders.

InSilicoTrials is an emerging startup founded by a team of life science, cybersecurity and digital innovation experts, which aims to revolutionize healthcare through an innovative modeling & simulation platform. InSilicoTrials has created a vertical software solution that integrates cutting-edge AI and simulation tools with the goal of helping pharmaceutical, medtech companies and researchers develop new drugs more efficiently and at a lower cost by reducing the need for traditional, time-consuming, and expensive clinical trials.

Additionally, the solution contributes to the reduction, refinement, and replacement of in vitro, animal, and human testing methods. InSilicoTrials built up an ecosystem of more than 70 scientific collaborations, where computational models are developed with internationally recognized universities and research centers, offering access to the highest level of data security.  With its cloud-based platform offering advanced M&S tools to perform in silico trials analyses, InSilicoTrials supports companies to integrate AI and simulation technology into their drug development workflows. 

Axoltis Pharma is a French biopharmaceutical company dedicated to developing a first-in-class disease-modifying drug to treat patients with neurodegenerative or traumatic neurological disorders with high unmet medical needs. NX210c, an innovative and promising drug-candidate, is a small peptide derived from SCO-spondin, a glycoprotein essential for neurogenesis during embryogenesis.

This disease-modifying drug candidate has three main properties: recovery of blood brain barrier integrity, neuroprotection, and enhancement of neurotransmission. These properties are very useful in the treatment of multiple neurodegenerative diseases, especially as there is strong evidence that blood brain barrier dysfunction promotes disease progression from early stages of the disease.

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charge.xyz joins peaq to build a community-powered P2P electric vehicle charging platform

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peaq, the layer-1 blockchain for DePIN and Machine RWAs (real-world assets), announces the expansion of its ecosystem as charge.xyz joins in. charge.xyz is building a DePIN enabling global peer-2-peer charging via community-owned electric vehicle chargers. The project has already completed the proof-of-concept version of its dApp and is now preparing for a mobile release that will feature initial core functionalities to onboard users. A full-on integration with peaq leveraging peaq’s Modular DePIN Functions and other DePIN-focused benefits will follow later in the year.

While electric vehicles are growing more popular, their adoption is not without hurdles. The lack of supporting infrastructure, especially compatible charging points, is one such challenge — to the point where concerns about charger availability deters people from buying electric vehicles. Millions of existing residential and privately-owned electric vehicle chargers could greatly expand the availability of charging and boost electric vehicle adoption without any investment needed.

charge.xyz works to close this gap by enabling charger owners to offer their charging points to the public, selling charging sessions to those in need. After joining its DePIN, wallbox (charging point) owners will be able to customize the availability of their chargers in line with their needs, set their price rates, and review the charger’s use logs.

charge.xyz is tapping peaq as its layer-1 blockchain and will leverage its Modular DePIN Functions as part of its core architecture and business logic. It will leverage peaq IDs as the identity standard for the DePIN, build the smart contracts powering the key interactions within its network on peaq, and use peaq as its payments and data storage layer. It is also exploring prospective synergies and partnerships within peaq’s ecosystem of more than 25 DePINs and world-leading enterprise partners.

At the current stage, the project is working on a mobile app which will enable people to register their chargers and electric vehicles on its DePIN. The app’s other features will include the ability to register historic charging sessions and write reviews to chargers, making for an open and transparent P2P-marketplace. More community-facing initiatives are also on their way.

“The fragmentation of the charging infrastructure landscape and existing players in the market playing the zero sum game are the biggest hurdles for the adoption of the global EV-revolution and a greener mobility paradigm,” says Dominic Klopsch, co-founder of charge.xyz.

“charge.xyz is addressing this challenge while also empowering anyone to be part of the push for a more sustainable future. peaq is the perfect layer-1 for this, as no other blockchain delivers such powerful fundamentals as well as a vast set of DePIN-specific functions. We look forward to building and launching on peaq and see unlimited potential synergies within its wide ecosystem of DePINs and top enterprises,” adds Fabian Poehler, co-founder at charge.xyz.

“One thing is certain: decentralized charging will lead to greater acceptance of electric cars,” says Leonard Dorlöchter, co-founder of peaq. “Decentralized charging is probably one of the most straightforward machine economy use cases. It will greatly reduce fragmentation of charging infrastructure and solve a fundamental issue for electric vehicle adoption — charger availability. We’re excited to see charge.xyz take on this important mission, choosing peaq as its layer-1, and are certain that the benefits to the peaqosystem and end-users are immense.”

The post charge.xyz joins peaq to build a community-powered P2P electric vehicle charging platform appeared first on HIPTHER Alerts.

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Blockchain Press Releases

Bitget Appoints Gracy Chen as CEO

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VICTORIA, Seychelles, May 21, 2024 /PRNewswire/ — Bitget, the leading cryptocurrency exchange and Web 3 company, today announces the appointment of Gracy Chen as its new Chief Executive Officer (CEO), effective in May 2024, succeeding Sandra Lou, who will be leaving the platform to pursue her own business goals. With over 10 years of experience in business management, marketing, and investment, Gracy proves herself to be a leading female entrepreneur in the crypto world.

Since 2014, as a notable TV host, Gracy found herself increasingly drawn into the dynamic world of blockchain technology, hence, cryptocurrencies through her interactions with knowledgeable guests like Tim Draper. Each interview not only enriched her show but also deepened her fascination with this emerging field. Her growing passion for the subject soon evolved to invest in several crypto startups, including Bitkeep (currently Bitget Wallet), the largest Web 3 multi-chain wallet in Asia.

In June 2022, Gracy joined Bitget as its first Managing Director (MD), leading Bitget’s growth strategies as the platform accelerates its global expansion plan. Over the past two years, her exceptional ability to manage and inspire multinational decentralized teams has been instrumental in navigating the fast-paced and highly competitive cryptocurrency landscape. One of her most remarkable achievements was co-leading the strategy that quadrupled Bitget’s user base through partnerships with legendary footballer Leo Messi as well as the establishment of a robust global affiliate network. This solidified Bitget’s position as a top-five crypto exchange and Web 3 platform.

“I’m extremely honored to step into the role of CEO at Bitget,” said Gracy Chen. “Over the past six years, with the robust foundation we’ve built and an incredible team by my side, Bitget has transformed into a leading crypto platform. By consistently innovating in product offerings and creating value for our 25 million users, Bitget has risen to become a top 5 futures trading platform and a top 10 spot trading platform. I’m thrilled to continue to be part of shaping this industry that is on the edge of innovation, empowering the future of digital finance. It’s a privilege to lead such a dynamic group and I can’t wait to steer our global expansion to new heights!”

Gracy is also advocating for a more diverse and inclusive crypto industry by leading two Corporate Social Responsibility (CSR) initiatives at Bitget. She spearheaded the launch of the #Blockchain4Youth campaign in May 2023, aiming to drive Web 3 adoption by inspiring the younger generation to embrace crypto and blockchain. The activity partnered with over 50 educational institutions and benefits over 6,000 young talents in just one year. As a key initiator of Bitget’s #Blockchain4Her initiative, her vision for a sustainable future involves integrating inclusivity and gender diversity into the blockchain industry, ensuring females have equal opportunities and representation in this transformative sector.

Beyond her responsibilities at Bitget, Gracy is proactively seeking opportunities to contribute to the cryptocurrency field. As a columnist for major publications such as Forbes and Cointelegraph, she has published over 50 articles to introduce blockchain to the public. She is also known as a judge of the first reality crypto TV show Killer Whales, a program co-created by Hollywood producers. The show aims to discover promising Web 3 projects and empower them to make a real-life impact. Her contributions earned her recognition as a Global Shaper by the World Economic Forum in 2015, and she was elected to the Forbes Business Council in 2023.

Gracy holds a Bachelor’s Degree from the National University of Singapore (NUS) and an MBA degree from the Massachusetts Institute of Technology (MIT).

About Bitget

Established in 2018, Bitget is the world’s leading cryptocurrency exchange and web3 company. Serving over 20 million users in 100+ countries and regions, the Bitget exchange is committed to helping users trade smarter with its pioneering copy trading feature and other trading solutions. Formerly known as BitKeep, Bitget Wallet is a world-class multi-chain crypto wallet that offers an array of comprehensive Web3 solutions and features including wallet functionality, swap, NFT Marketplace, DApp browser, and more. Bitget inspires individuals to embrace crypto through collaborations with credible partners, including legendary Argentinian footballer Lionel Messi and official eSports events organizer PGL.

For more information, visit: Website  |  Twitter  |  Telegram  |  LinkedIn  | Discord | Bitget Wallet

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Blockchain Press Releases

Bybit Reaches 30 Million Registered Users, Marking Explosive Growth and Industry Leadership into Web3

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DUBAI, UAE, May 21, 2024 /PRNewswire/ — Bybit, one of the world’s top three crypto exchanges by trading volume, today celebrates a monumental milestone: surpassing 30 million registered users globally. This remarkable achievement comes alongside a period of exceptional growth, solidifying Bybit as a frontrunner in the blockchain industry.

Market Share Soars, User Trust Flourishes

Bybit’s market share in spot trading has skyrocketed from 2% in 2023 to a staggering 9.3% in 2024, a nearly 400% surge according to the latest Kaiko Research quarterly report. This significant leap from the previous year’s 7.3% firmly establishes Bybit as a leader in cryptocurrency exchange.

Bybit attributes this growth to its unwavering commitment to user security and trust. The company prioritizes asset safety through the regular publication of proof-of-reserve audits, ensuring transparency and accountability with user funds. Additionally, Bybit boasts an impeccable security record, with no major breakdowns or hacking incidents since its inception in 2018.

This dedication to security and transparency is further validated by industry recognition. Bybit has received a perfect 10/10 Trust Score from CoinGecko and an ‘AA’ rating in the recent CCData Crypto Exchange Benchmark Report.

“Reaching 30 million registered users is a humbling achievement, and it wouldn’t be possible without the unwavering support of our vibrant global crypto community,” said Ben Zhou, Co-founder and CEO of Bybit. “We are incredibly grateful for their trust and remain committed to providing best-in-class, reliable services tailored to local needs. Bybit actively collaborates with regulators worldwide to ensure compliance and responsible innovation.”

Looking Forward: Bridging the Gap to Web3

Bybit has consistently been at the forefront of Web3 innovation, reshaping how users interact with the blockchain ecosystem through user-centric and engaging platforms. In 2024, we have expanded our suite of offerings with breakthrough solutions like the Airdrop Arcade, NFT Pro, and Inscription Marketplaces.

These platforms are meticulously designed not only to lower entry barriers and simplify the user experience but also to enrich it by curating opportunities to invest in and support a diverse range of promising, trending, and blue-chip tokens and projects. Our most recent Solana Fiesta and Bitcoin economy livestream introduced many Web3-curious individuals to the fast-growing ecosystems and their opportunities.

This curation consistently ensures that our users have access to the most rewarding and reliable opportunities in the Web3 space, making participation not only easier but also more enjoyable through gamification and advanced data intelligence. This commitment extends to the upcoming launch of Bybit Web3 DEX Pro, a cutting-edge decentralized exchange platform powered by revolutionary i-SMART data intelligence technology. This represents Bybit’s commitment to innovation that empowers, providing tools that not only meet but exceed the needs of modern traders and investors.

“Today’s milestone signifies more than just numbers; it’s a testament to our ongoing dedication to revolutionizing the crypto landscape,” emphasized Zhou. “Bybit remains committed to shaping the future of crypto. We will continue to uphold the values of listening, caring, and improving, to serve our 30 million users with the most professional products. Protecting the interests of our clients will be ingrained in all product designs. We envision a world where Web3 empowers every individual, where financial inclusivity is not just a goal but a reality.”

#Bybit / #TheCryptoArk / #BybitWeb3

About Bybit

Bybit is one of the world’s top three crypto exchanges by trading volume with over 30 million users. Established in 2018, Bybit offers a professional platform where crypto investors and traders can find an ultra-fast matching engine, 24/7 customer service, and multilingual community support. Bybit is a proud partner of Formula One’s reigning Constructors’ and Drivers’ champions: the Oracle Red Bull Racing team.

For more details about Bybit, please visit Bybit Press.
For media inquiries, please contact: [email protected]
For more information, please visit: https://www.bybit.com
For updates, please follow: Bybit’s Communities and Social Media

Discord | Facebook | Instagram | LinkedIn | Reddit | Telegram | TikTok | X | Youtube

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