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InSilicoTrials and Axoltis Pharma Collaborate to Advance Therapeutic Solutions for Neurological Disorders

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MILAN, July 27, 2023 /PRNewswire/ — InSilicoTrials, a leading provider of artificial intelligence (AI) and simulation tools for drug and medical device development, has embarked on a collaborative partnership with Axoltis Pharma, a biopharmaceutical company committed to developing disease-modifying drugs for patients with high unmet medical needs in neurodegenerative and traumatic neurologic impairments. This strategic collaboration works to revolutionize our understanding of Central Nervous System (CNS) diseases and to optimize the clinical development plan of Axoltis’ drug candidate, NX210c, a promising 12-amino acid peptide derived from SCO-spondin. 

 

The primary focus of this partnership is to utilize the InSilicoTrials’ platform and leverage its InSilicoNEURO suite, which encompasses a variety of mechanistic CNS models. More specifically, the models within InSilicoNEURO will be used to assess the impact of Axoltis’ drug candidate on virtual patients with different conditions, including Amyotrophic Lateral Sclerosis (ALS), Parkinson’s Disease and Multiple sclerosis (MS). Mechanistic CNS models are designed to simulate the physiological and pathological aspects of CNS disorders, providing insights into the disease mechanisms and potential therapeutic interventions. Integrating knowledge from various data sources, these models help researchers and clinicians understand the complex interactions within the CNS and contribute to the development of improved diagnostics and disease-modifying treatments for CNS disorders. 

Neurodegenerative conditions are often characterized by several common features, including blood-brain barrier leakage, synaptic transmission deteriorations, and neuron apoptosis. Given that Axoltis drug candidate NX210c targets these features, the collaboration with InSilicoTrials holds great promise for supporting CNS functions in a wide range of neurological and neurodegenerative conditions. By utilizing the InSilicoTrials’ digital platform and leveraging Phase Ib clinical trial data and the preclinical package, the collaboration works to assess the relationship between NX210c dosing regimens, blood brain barrier repair and neurological function, biomarker concentrations, and ultimately clinical efficacy and safety endpoints, through computational modeling and simulation (CM&S) and AI techniques

Unlocking the potential of artificial intelligence and computational modeling, the two companies work to accelerate research and development, minimize costs, and optimize time utilization.  

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We are thrilled to collaborate with Axoltis in our shared mission to advance therapeutic solutions for neurological disorders,” said Luca Emili, CEO of InSilicoTrials. “This partnership represents an exciting synergy between cutting-edge simulation technologies and innovative biotechnological advancements. Together, we aim to unlock new insights and develop groundbreaking treatments that will positively impact the lives of patients with neurologic impairments worldwide.” 

Dr. Yann Godfrin, CEO of Axoltis stated: “We are very delighted to initiate this collaboration with InSilicoTrials and have the opportunity to optimize and accelerate our next clinical steps. Integrating their industry-leading AI and computational modeling solutions in the development plan of our promising disease-modifying drug will allow us to address the pressing challenges faced by individuals suffering from neurological disorders.

InSilicoTrials is an emerging startup founded by a team of life science, cybersecurity and digital innovation experts, which aims to revolutionize healthcare through an innovative modeling & simulation platform. InSilicoTrials has created a vertical software solution that integrates cutting-edge AI and simulation tools with the goal of helping pharmaceutical, medtech companies and researchers develop new drugs more efficiently and at a lower cost by reducing the need for traditional, time-consuming, and expensive clinical trials.

Additionally, the solution contributes to the reduction, refinement, and replacement of in vitro, animal, and human testing methods. InSilicoTrials built up an ecosystem of more than 70 scientific collaborations, where computational models are developed with internationally recognized universities and research centers, offering access to the highest level of data security.  With its cloud-based platform offering advanced M&S tools to perform in silico trials analyses, InSilicoTrials supports companies to integrate AI and simulation technology into their drug development workflows. 

Axoltis Pharma is a French biopharmaceutical company dedicated to developing a first-in-class disease-modifying drug to treat patients with neurodegenerative or traumatic neurological disorders with high unmet medical needs. NX210c, an innovative and promising drug-candidate, is a small peptide derived from SCO-spondin, a glycoprotein essential for neurogenesis during embryogenesis.

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This disease-modifying drug candidate has three main properties: recovery of blood brain barrier integrity, neuroprotection, and enhancement of neurotransmission. These properties are very useful in the treatment of multiple neurodegenerative diseases, especially as there is strong evidence that blood brain barrier dysfunction promotes disease progression from early stages of the disease.

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Blocks & Headlines: Today in Blockchain – May 5, 2025 – Arkham, Blockchair, Worldcoin, Maldives

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In an ecosystem defined by perpetual innovation and high-stakes regulatory scrutiny, the blockchain and cryptocurrency industry never pauses. Today’s briefing—“Blocks & Headlines: Today in Blockchain – May 5, 2025 – Arkham, Blockchair, Worldcoin, Maldives”—dives into five compelling stories shaping the narrative: a transformative $9 billion blockchain hub in the Maldives; Sam Altman’s Worldcoin orbs arriving stateside; AI‑enhanced onchain visibility via Arkham and Blockchair; the Blockchain Association’s plea for flexible SEC oversight; and Telegram’s blockchain‑inspired encryption for massive group calls.

Together, these developments spotlight five interlocking themes: diversification of traditionally tourism‑dependent economies, identity and trust models in Web3, the fusion of AI with onchain data, the evolving policy landscape, and privacy‑centric encryption. Across these stories, recurring SEO keywords—blockchain, cryptocurrency, Web3, DeFi, NFTs, tokenization, decentralized identity, onchain analytics, regulation, and privacy—underscore the connective tissue binding today’s headlines.


1. $9 Billion Blockchain Hub on Track to Transform Maldives

Source: U.Today

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The Maldives, an archipelagic nation whose economy is heavily tethered to tourism (approximately 30 % of GDP) and fishing (around 10 %), is confronting mounting fiscal challenges: public debt has breached national GDP levels (circa $7 billion), and deficits threaten sovereign stability. In a strategic pivot, Maldivian authorities signed a joint venture with MBS Global Investments—a $14 billion UAE family office—earmarking an $8.8 billion investment in a cutting‑edge blockchain hub. This initiative aims to catalyze a 200 % GDP surge within four years, spawning thousands of jobs and potentially averting sovereign default.

On the surface, relocating blockchain infrastructure to paradise may seem incongruous. Yet by repurposing the country’s geographically dispersed islands into a decentralized Web3 nexus, the Maldives could host data centers powered by renewable oceanic energy, attract DeFi startups, and incubate NFT marketplaces catering to affluent tourists. This diversification blueprint underscores a broader trend: small economies leveraging blockchain to transcend traditional growth constraints. However, critical questions loom—regulatory clarity, environmental footprint, and cybersecurity resilience will determine whether this hub becomes a scalable model or a stranded asset.

Implication: If executed judiciously, the Maldives’ blockchain hub could set a precedent for emerging economies seeking to harness decentralized infrastructure. But success hinges on transparent governance, sustainable energy sourcing, and robust legal frameworks.


2. Altman’s Eyeball‑Scanning Worldcoin Orbs Land in the U.S.

Source: The Register

On May 1, six Worldcoin “Orb” retail locations opened across the United States—Austin, Atlanta, Los Angeles, Miami, Nashville, and San Francisco—offering biometric iris scans in exchange for WLD crypto tokens. Co‑founded by Sam Altman (OpenAI CEO), Alex Blania, and Max Novendstern, Tools for Humanity champions World ID, a blockchain‑based proof‑of‑personhood system designed to authenticate humans versus bots or AI‑generated avatars. Users who scan their irises receive roughly $16 in WLD, enabling them to later verify identity on participating platforms.

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While touted as a breakthrough in decentralized identity, the initiative has incited privacy regulators worldwide: South Korea fined the project over $800,000, Hong Kong prohibited operations, and legal probes are active in Germany, Kenya, and Spain. Yet Worldcoin maintains that biometric data is encrypted on-device and purged post‑scan, and with 26 million users globally (12 million scanned), the network seeks to deploy 7,500 Orbs in the U.S. by year’s end.

Opinion: Worldcoin’s retail push exemplifies the friction between innovative identity solutions and privacy norms. The on‑chain distribution of WLD tokens may democratize crypto access, but it also risks normalizing biometric collection without exhaustive regulatory guardrails. The debate between security and civil liberties intensifies as Web3 projects blur lines between voluntary onboarding and pervasive surveillance.


3. AI and Blockchain Explorers ‘Arkham’ & ‘Blockchair’ Reshape Onchain Visibility

Source: Bitcoin News

Blockchain explorers have evolved from static transaction trackers to dynamic investigative platforms, especially with generative AI integration. Two frontrunners—Arkham Intelligence and Blockchair—are pioneering tools to render cryptographic ledgers comprehensible. Arkham’s AI correlates onchain flows with off‑chain entities, enabling analysts to dissect a Binance transaction involving 0.3065 BNB routed through WBNB and Pancakeswap in seconds. Blockchair’s AI assistant, Cuborg, fields natural‑language queries (e.g., “Which Bitcoin address dormant since 2017 just moved funds at block 895,197?”), surfacing actionable intelligence with remarkable speed.

The convergence of machine learning and onchain analytics promises unprecedented transparency for DeFi protocols, NFT markets, and compliance teams. Yet this visibility shift also rekindles the age‑old privacy dilemma: as attribution sharpens, users may flee to privacy coins (e.g., Monero, Zcash) or sophisticated mixers, fracturing onchain provenance. Thus, the community must strike a balance—leveraging AI for due diligence without undermining pseudonymity, a bedrock of decentralization.

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Takeaway: Enhanced onchain visibility emboldens regulators and institutional custodians to adopt crypto, but it simultaneously pressures privacy advocates to innovate. The trajectory of DeFi scalability and AML compliance will pivot on how explorers calibrate the transparency‑privacy spectrum.


4. Blockchain Association Urges SEC to Adopt Flexible Crypto Regulation

Source: The Block Binance

On May 2, the Blockchain Association—representing heavyweights such as Coinbase, Ripple, and Uniswap Labs—submitted formal comments urging the U.S. Securities and Exchange Commission (SEC) to embrace an “incremental, flexible approach” under new Chair Paul S. Atkins. The association argued that equity‑style rule frameworks ill‑fit blockchain’s decentralized architecture, and that overly restrictive policies risk ceding global leadership in Web3 innovation. Key recommendations included:

  • Modernizing “best execution” by prioritizing diligence over prescriptive equity norms.

  • Leveraging public exchange APIs for oversight, eschewing bulk personal data collection.

  • Convening public‑private roundtables to iteratively refine tokenization guidelines.

As the SEC grapples with litigation against major crypto firms, the association’s plea underscores a broader policy shift—from adversarial enforcement to collaborative rulemaking. If embraced, this could catalyze a regulatory renaissance, aligning U.S. competitiveness with nascent markets such as the EU’s MiCA and Singapore’s digital asset frameworks.

Analysis: A flexible U.S. regime could anchor global capital flows in American markets. However, in the near term, ambiguity may persist, prompting projects to seek out friendlier jurisdictions. The evolution of DeFi, tokenized securities, and NFT financialization hinges on whether the SEC transitions from litigation‑driven oversight to principles‑based governance.

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5. Telegram’s Blockchain‑Inspired Encryption Empowers Massive Group Calls

Source: CCN.com

Messaging titan Telegram has rolled out a major security upgrade: blockchain‑inspired encryption for voice and video group calls, scaling to tens of thousands of participants. Published May 5, 2025, the update employs a distributed architecture reminiscent of blockchain’s consensus model, paired with end‑to‑end encryption and a novel four‑emoji verification system. Users can join calls via links, QR codes, or invites, accommodating up to 200 guests in peer‑to‑peer calls and vastly more in server‑mediated group sessions.

This enhancement cements Telegram’s Web3 orientation—from in‑app NFT galleries to integrated crypto wallets and June’s Grok AI chatbot. By emphasizing decentralized encryption, Telegram seeks to differentiate itself from legacy platforms and curry favor with privacy‑minded Web3 users. The $100,000 unclaimed bounty for encryption breaches further testifies to the platform’s confidence.

Perspective: As social channels become conduits for DAO assemblies, token launches, and remote governance, Telegram’s upgrade anticipates Web3 ’s communal demands. Secure, large‑scale calls could host multichain hackathons, decentralized grant panels, and NFT minting drop parties—ushering in an era where encrypted communications seamlessly integrate with onchain action.


Conclusion: Charting Tomorrow’s Web3 Horizon

Today’s headlines—from island‑wide blockchain sanctuaries to AI‑powered explorers, from biometric orbs to regulatory overtures and encrypted megacalls—illustrate the multifaceted momentum driving blockchain and crypto into mainstream orbit. Key takeaways include:

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  1. Economic Diversification via Blockchain: Smaller nations can pivot from tourism to tech‑led growth, provided they embed sustainability and legal clarity.

  2. Identity & Privacy Trade‑Offs: Worldcoin’s iris scans provoke essential dialogue on biometric ethics versus Sybil‑resistance in decentralized networks.

  3. AI‑Driven Transparency: Arkham and Blockchair spotlight the accelerating fusion of AI and onchain analytics, demanding new privacy paradigms.

  4. Adaptive Regulation: The Blockchain Association’s SEC proposal signals burgeoning alignment between policymakers and innovators—critical for U.S. leadership.

  5. Web3‑First Infrastructure: Telegram’s encryption upgrade underscores the imperative for platforms to bake decentralized security into every layer.

As the industry hurtles forward, stakeholders must navigate these cross‑currents with pragmatic vision—embracing decentralization, protecting user sovereignty, and fostering constructive policy engagement. Tomorrow’s decentralized economy may hinge as much on robust encryption and AI transparency tools as on visionary regulation and sustainable infrastructure projects.

 

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Blockchain Press Releases

Bybit Spread Trading: An Innovative Product to Streamline Advanced Trading Strategies

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DUBAI, UAE, May 5, 2025 /PRNewswire/ — Bybit, the world’s second-largest cryptocurrency exchange by trading volume, is proud to announce the launch of Spread Trading. This new trading functionality streamlines the previously more manual technical crypto trading environment — enabling crypto traders to access markets faster and at lower cost — now available via Bybit’s intuitive platform.

As uncertainty becomes a constant theme in financial markets, and ongoing price fluctuations test traders’ risk appetite, Bybit’s Spread Trading offers a timely solution for investors seeking to capitalize on price differences between corresponding crypto assets, without the previously heavier risk management and markets access complexities traditionally associated with such trading crypto strategies.

Spread trading comes with a wide range of benefits on Bybit: 

  • Guaranteed Spread Execution: The entry spread exactly matches the order price set by the user, eliminating slippage concerns.
  • Precise Execution: Both positions are filled simultaneously or not at all, removing the “leg risk” of incomplete trades.
  • Risk Hedging: Offsetting market swings by taking opposite positions in correlated assets.
  • Strategic Flexibility: Diversifying strategies including Funding Rate Arbitrage, Futures Spread, Carry Trade, or Perpetual Basis trading.
  • Lower Costs: The feature stands to save traders 50% of the fees compared to placing separate orders manually.

What is Spread Trading

Spread trading is a strategy where traders simultaneously buy one crypto asset while selling another related one, allowing them to profit from the price difference (spread) between them rather than from overall market direction. Bybit simplifies the process by combining both trades into a single transaction and precise entry points, eliminating timing risks and execution issues.

The strategy works by pairing related instruments, such as Spot and Perpetual contracts, or two different Expiry contracts, in equal but opposite positions, creating a delta-neutral approach that protects traders from broad market volatility. 

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Bybit’s Spread Trading feature currently supports four trading combinations: Expiry & Expiry contracts, Expiry & Perpetual contracts, Expiry & Spot markets, and Perpetual & Spot markets. The service is available for BTC, ETH, and SOL with plans to expand to additional digital assets.

Bybit users may now power up their trades and ride the highs and lows of the crypto markets with ease. Terms and conditions apply. To find out more about the feature and how it works, users may visit: How to Get Started With Spread Trading

#Bybit / #TheCryptoArk

About Bybit

Bybit is the world’s second-largest cryptocurrency exchange by trading volume, serving a global community of over 60 million users. Founded in 2018, Bybit is redefining openness in the decentralized world by creating a simpler, open and equal ecosystem for everyone. With a strong focus on Web3, Bybit partners strategically with leading blockchain protocols to provide robust infrastructure and drive on-chain innovation. Renowned for its secure custody, diverse marketplaces, intuitive user experience, and advanced blockchain tools, Bybit bridges the gap between TradFi and DeFi, empowering builders, creators, and enthusiasts to unlock the full potential of Web3. Discover the future of decentralized finance at Bybit.com.

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For more details about Bybit, please visit Bybit Press
For media inquiries, please contact: media@bybit.com
For updates, please follow: Bybit’s Communities and Social Media

Discord | Facebook | Instagram | LinkedIn | Reddit | Telegram | TikTok | X | Youtube

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Blockchain Press Releases

CoolBitX Launches CoolWallet Go: The World’s First Cold Wallet with Lifetime Warranty

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TAIPEI, May 5, 2025 /PRNewswire/ — CoolBitX officially introduces CoolWallet Go, a minimal, ultra-portable cold wallet designed for new crypto users and seasoned holders alike. It’s a next-generation card wallet focused on simplicity, cost-efficiency, and everyday utility—without compromising on security fundamentals.

Pre-Order Offer (April 21May 10)

CoolWallet Go is now available for pre-order at $59.99 USD for a 2-card set. Customers can optionally add a lifetime warranty plan for $39 USD per set—a rare offering in the cold wallet space.

Simple, Secure, and Built for Daily Use

CoolWallet Go is built around a CC EAL6+ certified secure element, a proven protection standard used in many high-assurance security chips. The wallet’s minimalist design includes no screen, no buttons, no battery, and no Bluetooth pairing, relying instead on tap-to-sign NFC to streamline transactions.
The device generates private keys directly on-card, minimizing exposure during wallet setup. Users manage assets via the CoolWallet App, with integrated support for Bitcoin, Ethereum, 40+ blockchains, and EVM-compatible tokens.

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Security and Risk Awareness by Design

CoolWallet Go has undergone independent third-party security testing and has been continuously reviewed through a public bug bounty program over the past two years. No vulnerabilities have been found that compromise the safety of users’ private keys or assets. CoolBitX remains committed to continuous security improvement and transparent security practices.

Optional Lifetime Warranty Plan

CoolWallet Go introduces a unique warranty add-on that provides long-term coverage for registered users:

  • Coverage is per 2-card set, with a quota of free replacements per year.
  • Registration is required within 30 days of purchase.
  • Shipping costs for replacements are customer-borne.
  • Warranty resets yearly and is not cumulative.

This initiative reflects CoolBitX’s commitment to sustainable product longevity, moving beyond traditional short-cycle hardware support.

Built for Beginners, Trusted by Pros

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CoolWallet Go is ideal for:

  • First-time hardware wallet users transitioning from exchanges or hot wallets.
  • Experienced holders looking for a compact, secure backup or daily-use wallet.

Shipments begin mid-May.
Pre-order and learn more here: https://reurl.cc/Lanld7
Download the CoolWallet App

  • Google Play
  • Apple App Store

About CoolWallet

CoolWallet is a pioneering hardware wallet brand that offers a secure and convenient solution for storing and managing digital assets in the Web3, DeFi, and NFTs arenas. The company’s flagship product, the CoolWallet Pro, is a credit card-sized device that combines the security of a hardware wallet with the convenience of a mobile device. With its unique design and advanced security features such as an EAL6+ secure element, biometric verifications, and military-grade Bluetooth encryption, CoolWallet is committed to providing a safe and user-friendly platform for crypto users worldwide.

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