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Cumulus Neuroscience Presents Data at AAIC 2023 Annual Meeting and Technology and Dementia Preconference

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  • Interim analysis of first-in-class CNS-101 study suggests that patients with mild Alzheimer’s dementia are capable and willing to participate in intensive home-based functional neurophysiology studies.

BELFAST, Northern Ireland and CAMBRIDGE, Mass., July 17, 2023 /PRNewswire/ — Cumulus Neuroscience (Cumulus; The Company), a global digital health company focused on advancing neuroscience clinical trials and patient care through improved data, presented interim data from their real-world feasibility study CNS-101 at the Alzheimer’s Association International Conference 2023 in Amsterdam, Netherlands. Using the proprietary Cumulus Neuroassessment Platform to gather data via repeated at-home sampling, the study is being conducted in collaboration with the University of Cambridge and Trinity Biomedical Science Institute.

Cumulus presented a poster titled, “Feasibility of real-world endpoints of functional neurophysiology in Alzheimer’s disease dementia,” which demonstrated that objective measures of a range of domains, including electroencephalogram (EEG), are user-friendly and suitable for repeated at-home use by patients and older controls. Patients living with Alzheimer’s dementia (AD) demonstrated high compliance rates with the study protocol (75%), when compared to the compliance rates of healthy controls (83.3%) during the initial 2-week burst stage. Importantly, despite the intensive at-home sampling schedule, drop-out rates in this ongoing study continue to be very modest (AD patients, 20%; healthy controls, 6%). Initial analyses of key endpoints demonstrated that behavioral and EEG-based measures aligned strongly with traditional clinical benchmarks, constituting positive early evidence for construct validity and technical feasibility.

“Clinic-based biomarkers are effective in tracking disease progression in clinical research but do not scale to support large real-world studies. Purely digital markers are scalable but lack objectivity,” said Brian Murphy, PhD, Founder and Chief Scientific Officer of Cumulus. “This interim analysis has provided confirmation that patients living with Alzheimer’s are capable and willing to participate in clinical studies that include at-home EEG, and that our platform is user-friendly and suitable for repeated at-home use. We were encouraged to see high compliance rates with the study protocol, and low dropout rates. We are grateful to all the study participants and research collaborators.”

AD is a progressive disease that affects brain function, memory, and other cognitive abilities. It is the most common cause of dementia, affecting millions of people worldwide. Symptoms usually develop slowly and worsen over time, including memory loss, confusion, difficulty with language and communication, mood swings, and changes in behavior and personality. Currently, there is no known cure for AD.

In a second poster presentation, researchers from Boston University Chobanian & Avedisian School of Medicine presented data generated in part from the Cumulus Neuroassessment Platform titled, “Implementing wearable technologies for in home assessment of cognitive and event-related potential responses after sleep and wakefulness in Alzheimer disease.” The primary aim of the study was to explore the feasibility of using wearable technologies to support the collection of quality clinical study data at home. The study demonstrated that this type of study design was well accepted by patients, and consistent with the Cumulus study findings, there were high levels of adherence to the study protocol.

“This pilot study offers proof of concept that at-home data collection leveraging wearable technologies has the potential to enable screening, staging and monitoring of brain function longitudinally in clinical studies,” said Andrew Budson, MD, Professor of Neurology at Boston University Chobanian & Avedisian School of Medicine. “We were encouraged to see excellent levels of patient adherence to the study protocol. Importantly, the remote data captured in this study was of similar quality to data generated using traditional methods in house at Boston University.”

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In the CNS-101 Study, patients with AD (N=59) and healthy controls (N=60) were recruited for a 1-year repeated sampling study in the UK. Patients were clinically assessed to have mild AD. Participants were asked to complete repeated home-based sessions of approximately 30 minutes of behavioral tasks including memory, executive function, affective processing, and language, while synchronized EEG was recorded using the Cumulus 16-lead EEG headset. All study participants completed a 2-week burst stage which included a total of 15 sessions.

Cumulus supports precision in CNS clinical trials for its industry partners by enabling remote monitoring of patients across multiple domains of brain function. To learn more, visit www.cumulusneuro.com.

Dr. Budson and his team receive funding and other resources from Bristol Myers Squibb and Cumulus Neuroscience.

About Cumulus Neuroscience
With a mission to generate the data and insights required to accelerate diagnosis and management of central nervous system (CNS) disorders for millions of patients and caregivers around the world, Cumulus Neuroscience is advancing an AI-based, multi-domain digital biomarker platform to enable better, faster decision making in neurology and neuropsychiatry clinical trials and patient care. Designed for and with 10 of the world’s leading pharma companies, the platform enables decentralized trials, and is already making a difference in the development of therapies for Alzheimer’s Disease, depression and schizophrenia.

Designed to provide an industry-wide standard for real-world measurement of disease progression, Cumulus combines patented technology, in-house expertise and key industry partnerships to capture large amounts of real-world, clinical data repeated over time, across multiple behavioral and physiological domains in the patient’s home – all with an EEG headset synced to a novel, tablet-based neuro-assessment platform. Together with machine learning (ML) analytics and the world’s largest database of annotated, longitudinal, neurofunctional data, Cumulus simplifies and improves the robustness of neuroscience clinical trials to provide the best and most cost-effective assessment of CNS treatment outcomes.

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The Company is supported by highly experienced specialized investors, DDF/SV Health Investors, LifeArc and Future Fund, and a world-class Scientific and Technical Advisory Board.

FOR MORE INFORMATION
Julie Dietel
FINN Partners for Cumulus
[email protected]
Tel: 978.502.7705

Logo – https://mma.prnewswire.com/media/1903807/Cumulus_Neuroscience_Logo.jpg 

View original content:https://www.prnewswire.co.uk/news-releases/cumulus-neuroscience-presents-data-at-aaic-2023-annual-meeting-and-technology-and-dementia-preconference-301878093.html

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Avalanche Joins Forces with Stripe: Transforming Crypto Purchases Across the US

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Avalanche, a leading blockchain platform, has partnered with Stripe to enhance the accessibility of its ecosystem. This strategic collaboration integrates Stripe’s fiat-to-crypto onramping capabilities directly into Avalanche’s C-Chain, enabling retail users to purchase the native cryptocurrency, AVAX, without the complexities of traditional crypto exchanges.

Integration and User Experience Enhancement

The integration aims to simplify the process of acquiring AVAX by embedding Stripe’s onramp as a customizable widget within various Avalanche decentralized applications (dApps). These dApps include decentralized exchanges (DEXes), NFT platforms, and digital wallets, facilitating a seamless and streamlined user experience. By leveraging Stripe’s infrastructure, users can easily fund their accounts using various payment methods, including ACH transfers and credit/debit cards.

Core Wallet Integration

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A key component of this collaboration is the integration into Core, Avalanche’s native ecosystem wallet developed by Ava Labs. Core wallet users can now directly fund their wallets via the Stripe widget, making it easier to engage with the Avalanche network. The wallet setup process is straightforward, allowing new users to create accounts using Gmail or Apple ID, thereby reducing the barriers to entry into the crypto space.

Addressing Web3 Challenges

This integration addresses several challenges commonly faced in the Web3 ecosystem, such as the “cold start problem,” where users lack initial funds to participate in transactions. Stripe’s onramp handles essential elements like KYC, payments, fraud prevention, and compliance, allowing dApps to focus on enhancing user experience rather than dealing with regulatory complexities.

The initiative is supported by key players in the Avalanche ecosystem, including GoGoPool, Avvy, Pakt, zeroone, Halliday, The Arena, Shrapnel, and DeFi Kingdoms. These partners, offering services from decentralized naming and gaming to financial and social interaction platforms, stand to benefit from the increased ease of access to digital asset transactions.

Promoting Web3 Adoption

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The collaboration between Avalanche and Stripe goes beyond simplifying transactions; it also aims to bridge the gap between traditional finance and the emerging Web3 landscape. By integrating a familiar and secure payment system, the partnership ensures that users, both new and existing, can navigate the cryptocurrency ecosystem with greater ease and confidence.

The leadership from both Ava Labs and Stripe has expressed enthusiasm about the partnership. Akash Gupta, Head of Consumer Products at Ava Labs, highlighted the commitment to user-centric solutions and broader adoption of digital currencies. John Egan, Head of Crypto at Stripe, noted that the initiative aligns with Stripe’s mission to democratize access to Web3 technologies, making them safer and more accessible to a global audience.

This strategic partnership is expected to accelerate consumer adoption, deepen user engagement, and reinforce Avalanche’s position as a leader in the blockchain industry.

Source: blockchainreporter.net

The post Avalanche Joins Forces with Stripe: Transforming Crypto Purchases Across the US appeared first on HIPTHER Alerts.

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BIGG Digital Assets Enhances Crypto Investigator Training with New Modules

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BIGG Digital Assets Inc. (CSE: BIGG, OTCQX: BBKCF), a prominent player in the Digital Asset, Blockchain, and Metaverse industries, has expanded its educational offerings through its subsidiary, Blockchain Intelligence Group (BIG). This expansion includes two new advanced training modules within the Certified Cryptocurrency Investigator (CCI) program, aiming to meet the increasing demand for specialized expertise in cryptocurrency investigations and compliance.

Overview of the New Advanced Training Modules

  1. Module 9: Hacks and Exploits in the Cryptocurrency Space
    • This module focuses on the various techniques employed by cybercriminals to exploit blockchain networks and digital assets. It includes comprehensive case studies of significant cryptocurrency hacks and exit scams, providing participants with a deep understanding of these threats. The training covers how to detect early warning signs and implement best practices to mitigate risks. Additionally, it addresses the role of the dark web in these activities, giving insights into how these criminal networks operate.
  2. Module 10: Cryptocurrency Compliance and Risk Management for Financial Institutions
    • Targeted at compliance officers, risk managers, and executives, this module provides in-depth training on establishing robust risk management frameworks and controls within financial institutions. It covers essential regulatory requirements, risk assessment methodologies, and due diligence processes necessary for safeguarding against cryptocurrency-related risks. This module also offers a standalone certification, Certified Cryptocurrency Investigator – Compliance (CCI-C), emphasizing its critical relevance in today’s regulatory landscape.

Significance and Industry Impact

Lance Morginn, President of BIG, highlighted the growing sophistication of cyber threats in the digital asset space, driven by increasing global adoption of cryptocurrencies. The new modules are designed to equip professionals with the necessary skills and intelligence to identify and counter these emerging threats. This initiative reflects BIG’s commitment to providing up-to-date and practical training that addresses the current and future challenges faced by the industry.

Robert Whitaker, overseeing Law Enforcement Affairs at BIG, emphasized the continuous evolution of BIG’s curriculum to keep pace with the rapidly changing digital asset landscape. This approach ensures that professionals are well-prepared to deal with both technical and regulatory aspects of cryptocurrency investigations and compliance.

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Certification and Professional Development

The new modules complete the Certified Cryptocurrency Investigator – Advanced (CCI-A) certification course, covering modules 6 to 10. This advanced certification is valid for one year, requiring a top-up course for renewal, which ensures that professionals remain current with the latest industry developments and best practices.

The foundational CCI certification has already been completed by over 2,500 professionals globally, including those from law enforcement, regulatory bodies, financial institutions, and the cryptocurrency sector. The courses are led by seasoned experts, including former federal agents and compliance officers, providing participants with invaluable practical knowledge and real-world insights.

Future Prospects

As the cryptocurrency industry continues to expand, the demand for specialized training and certifications like those offered by BIG will likely grow. These programs not only help professionals address existing challenges but also prepare them for future developments in the rapidly evolving digital asset space. Through these educational initiatives, BIGG Digital Assets Inc. and Blockchain Intelligence Group are making significant contributions to the security and integrity of the global cryptocurrency ecosystem.

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Source: cointrust.com

The post BIGG Digital Assets Enhances Crypto Investigator Training with New Modules appeared first on HIPTHER Alerts.

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Blockchain Intelligence Group adds additional modules and launches its Certified Cryptocurrency Investigator – Advanced Series

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BIGG Digital Assets Inc. has announced the launch of two new advanced modules in its Certified Cryptocurrency Investigator (CCI) training program through its subsidiary, Blockchain Intelligence Group (BIG). This expansion reflects the growing need for specialized knowledge in the digital asset and blockchain sectors, especially as these industries face increasingly sophisticated cyber threats.

New Modules Overview

  1. Module 9: Hacks and Exploits
    • This module provides an in-depth analysis of significant cryptocurrency hacks, exploits, and exit scams. It includes detailed case studies to help students understand the tactics employed by cybercriminals, identify early warning signs, and apply best practices for risk mitigation. The curriculum also covers the role of the dark web in facilitating these illegal activities.
  2. Module 10: Compliance and Risk Management
    • Aimed at professionals in financial institutions, this module covers comprehensive frameworks and controls for managing risks associated with cryptocurrencies. It includes regulatory requirements, risk assessment methodologies, and due diligence processes. The module offers a standalone certification, the Certified Cryptocurrency Investigator – Compliance (CCI-C), which is particularly valuable for compliance officers and risk managers.

Certification Details

The completion of these two modules, along with previous ones, leads to the Certified Cryptocurrency Investigator – Advanced (CCI-A) certification. This certification is valid for one year, after which professionals must complete a top-up course to maintain their certified status. The program is designed to equip investigators, compliance teams, and risk professionals with the latest intelligence and skills necessary to combat the challenges in the rapidly evolving digital asset landscape.

Industry Relevance

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As cryptocurrency adoption grows globally, the risks associated with blockchain networks and digital assets also increase. The introduction of these advanced modules is a proactive step by BIGG Digital Assets Inc. to address the need for continuous education and training in this dynamic field. The CCI program has already been adopted by over 2,500 professionals worldwide, including law enforcement, regulatory bodies, and financial institutions, demonstrating its critical role in enhancing industry standards and safeguarding against cyber threats.

Conclusion

BIGG Digital Assets Inc.’s continued investment in educational initiatives through the Blockchain Intelligence Group underscores the importance of preparedness and expertise in the cryptocurrency space. By staying at the forefront of training and compliance, the company supports the broader industry’s efforts to maintain security and integrity as digital assets become more integrated into global financial systems.

Source: globenewswire.com

The post Blockchain Intelligence Group adds additional modules and launches its Certified Cryptocurrency Investigator – Advanced Series appeared first on HIPTHER Alerts.

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