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Rznomics Presents Its Own Circular RNA Platform Technology

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SEONGNAM, South Korea, Aug. 3, 2023 /PRNewswire/ — Rznomics developed a novel platform technology termed ‘self-circularized RNA structure’ that can efficiently and simply generate circular RNA and overcome the limitations of existing technology. Rznomics published an article regarding its development strategy and efficacy in the journal ‘Molecular Therapy Nucleic Acids.’

Since the success of the COVID-19 vaccine, mRNA technology has been studied with great interest in various fields, such as vaccines and therapeutics. However, conventional linear mRNA is vulnerable to nucleases, and patent-protected modified nucleic acids need to be used for efficient protein expression with the reduction of unwanted immune responses.

To overcome the drawbacks of the conventional linear RNAs mentioned above, circular RNA structure technology has recently attracted attention. Circular RNA (circRNA) has a closed structure, so it has great stability against nucleases, and it has been reported that there are no influences on unwanted immune responses and protein expression without using the modified nucleotides. Therefore, if it is commercialized, circRNA vaccines or therapeutics will potentially be more competitive in price and will have the same efficacy equivalent to linear RNA in a smaller amount.

Attracting large-scale investments, a couple of major biotech companies in the U.S. lead the circRNA R&D industry and show the expectations from the market. In the case of one of these companies, they use a circRNA manufacturing technology based on group I intron ribozyme, called the Permuted Intron-Exon (PIE) method. The PIE method splits the ribozyme, which was used in the cis-splicing reaction to remove the intron and link the flanking exons, into half and connects each half of ribozyme to both ends of the GOI (Gene of interest) to make the circRNA with specific GOI. Since the immaturity stage of the circRNA field, there are rooms for biotech companies to enter the competition. However, to enter the market with competitiveness, the core & innovative platform technology that overcomes the limitations of existing technologies is essential.

Rznomics has developed a new circular RNA manufacturing technology that uses group I intron ribozyme as well. However, the technology is fundamentally different from the PIE method in the circularization mechanism. Rznomics has recently published its own circular RNA technology on line in Molecular Therapy Nucleic Acids (DOI: https://doi.org/10.1016/j.omtn.2023.07.034, Title; Efficient circular RNA engineering by end-to-end self-targeting and splicing reaction using Tetrahymena ribozyme), the official journal of the American Society for Gene and Cell Therapy (ASGCT). Rznomics applied its unique Tetrahymena trans-splicing ribozyme platform technology to effectively convert linear RNA into circular RNA by designing end-to-end self-targeting and splicing (STS) reaction. 

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As shown in the figure, an RNA construct was designed to connect the GOI at the end of the group I intron ribozyme. In this construct, the target site that can be targeted by ribozyme and IGS (Internal Guide Sequence) that guides the targeted trans-ligation by base-pairing with the target site were designed to locate at both ends to enable the circular RNA formation through a self-circularization reaction.

The most notable point is that in contrast to the PIE method, Rznomics’ circularization technology does not leave traces of non-necessary genetic information in the GOI (Gene of Interest) after the self-circularization reaction. In the case of PIE, the ribozyme needs to connect both ends of the GOI harboring extraneous specific nucleotide sequences to form a circular RNA. Whereas, in the case of STS reaction, the ribozyme leads to self-circularization by designing any target sequence present in GOI to be located at the end of GOI.

Also, Rznomics confirmed that circularization efficiency is comparable to the efficiency of the PIE method. In addition, due to the nature of the STS reaction, it is possible to establish various optimization strategies to increase the self-circularization efficiency, unlike the PIE method. It is considered that the self-circularization efficiency decreases as the length of the gene of interest. However, in the case of Rznomics technology, it is possible to screen an optimal target sequence that maximizes the efficacy of self-circularization. Rznomics stated that, through the STS-based reaction, long RNA such as human dystrophin RNA (11,265 nucleotides) was successfully self-circularized.

Moreover, a self-circularization reaction occurs simultaneously during in vitro transcription which is the process of synthesizing RNA. Therefore, the purification process can be directly initiated without any additional steps of the process. In the published paper, Rznomics also mentioned a method for purifying the circRNA using the IP-RP HPLC technique. The purified circRNA with unmodified nucleotides enabled more efficient and sustained protein expression without unwanted immune responses, compared with linear RNA with modified nucleotides.

This research was conducted with the support of the Ministry of Science & ICT and the National Research Foundation of Korea. The ‘Self-circularization RNA structure and Platform technology’ is a patent granted in South Korea (10-2442946) and has been applied in the U.S. and major countries.

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About Rznomics

As a biopharmaceutical company founded in the laboratory of Professor Seong-Wook Lee, Dankook University Department of Bioconvergence Engineering, Rznomics is researching with the goal of developing new RNA-based gene therapeutic bio-drugs for cancer and incurable diseases. Rznomics’ core platform technology is based on an RNA replacement enzyme, known as trans-splicing ribozyme, which can edit target RNA through simultaneous destruction and repair (and/or reprogramming) to yield the desired therapeutic RNA, thus, selectively inducing therapeutic gene activity in cells expressing the target RNA.

Rznomics’ lead candidate (RZ-001) is a treatment for Hepatocellular Carcinoma & Glioblastoma (Phase 1/2a IND approval from both in South Korea and in the U.S.), with other treatments for Alzheimer’s disease and hereditary retinal dystrophy (RD). For more information, please visit www.rznomics.com.

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[email protected] 

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Blockchain Press Releases

KuCoin Introduces Omnibus Account Structure to Enhance Liquidity for Brokerage Partners

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VICTORIA, Seychelles, July 19, 2024 /PRNewswire/ — July 23, 2024 – KuCoin, a leading cryptocurrency exchange, is pleased to announce a significant enhancement to its Broker Program, designed to cater to liquidity-seeking partners. This upgraded program enables participants to leverage KuCoin’s superior liquidity and diverse asset offerings across both Spot and Futures markets. With this enhancement, participants can now benefit from KuCoin’s top-tier liquidity, high-revenue shares, unlimited sub-accounts, and independent deposit addresses, allowing for functional flexibility and maintaining their own client management powers.

“Our new brokerage infrastructure is suitable for multiple types of institutional partners, such as crypto exchanges, execution terminals, layer 2 aggregators, OTCs, and traditional financial service providers venturing into crypto,” said Anton Starchenko, Director of Institution Business Development of KuCoin. 

“This upgrade demonstrates our commitment to providing our partners with the tools they need to succeed in the rapidly evolving crypto market.”

By joining the KuCoin brokerage service, brokers gain access to one main broker account with unlimited sub-accounts. Each sub-account features an exclusive deposit address, serving as a wallet to separate funds and trades. Additionally, each sub-account undergoes independent risk checks. These ongoing risk and compliance measures bolster KuCoin’s commitment to protecting partner interests. Broker accounts are subject to separate fee structures, while the broker receives a combined commission based on the cumulative volume across all accounts.

As a leading platform in the cryptocurrency industry, KuCoin is dedicated to providing top-notch security and reliability. The platform employs state-of-the-art security measures, including advanced encryption protocols, multi-factor authentication, and real-time monitoring systems to ensure the safety of users’ assets. KuCoin’s unwavering focus on security and innovation has solidified its reputation as a trusted and forward-thinking exchange in the global crypto market.

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For more information about the KuCoin Broker Program and the new omnibus account structure, please visit KuCoin’s official website.

About KuCoin

Launched in September 2017, KuCoin is a leading cryptocurrency exchange with its operational headquarters in Seychelles. As a user-oriented platform with a focus on inclusiveness and community engagement. It offers over 900 digital assets across Spot trading, Margin trading, P2P Fiat trading, Futures trading, and Staking to its 34 million users in more than 200 countries and regions. KuCoin ranks as one of the top 6 crypto exchanges. KuCoin was acclaimed as “One of the Best Crypto Apps & Exchanges of June 2024” by Forbes Advisor and has been included as one of the top 50 companies in the “2024 Hurun Global Unicorn List”. Learn more at https://www.kucoin.com/ .

Contact Us to Join

Telegram: @KuCoin_Broker

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Email: [email protected]

Book a Product Call here.

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Blockchain Press Releases

Bybit Launches Block Merchant Program, Offering Up to 3,000 USDT in Rewards

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DUBAI, UAE, July 19, 2024 /PRNewswire/ — Bybit, the world’s second-largest web3 platform by trading volume, announced the launch of its Block Merchant program, designed to empower users to maximize their earnings while buying or selling cryptocurrencies. Through this exciting initiative, Bybit aims to recognize and reward the valuable contributions of its P2P users.

By becoming a Bybit Block Merchant, users can unlock a range of exclusive benefits, including:

  • Lucrative USDT Merchant Rewards: Earn substantial rewards for buying or selling crypto.
  • Enhanced Visibility: Enjoy a prominent position on the platform with a special diamond label and higher priority than Bybit Verified Advertisers.
  • Increased Transaction Limits: Process larger transaction volumes with a single order limit raised to 200,000 USDT.
  • Priority Ad Ranking: Achieve top-tier visibility among advertisers under similar conditions.
  • Swift Appeal Resolution: Benefit from expedited customer service support for any issues.

Bybit is committed to providing its users with exceptional trading experiences and opportunities to thrive in the dynamic cryptocurrency market. The Block Merchant program reflects our commitment, offering users a chance to boost their income while contributing to the growth of the Bybit P2P ecosystem.

#Bybit / #TheCryptoArk

About Bybit

Bybit is the world’s second-largest cryptocurrency exchange by trading volume, serving over 33 million users. Established in 2018, Bybit provides a professional platform where crypto investors and traders can find an ultra-fast matching engine, 24/7 customer service, and multilingual community support. Bybit is a proud partner of Formula One’s reigning Constructors’ and Drivers’ champions: the Oracle Red Bull Racing team.

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For more details about Bybit, please visit Bybit Press.
For media inquiries, please contact: [email protected]
For more information, please visit: https://www.bybit.com
For updates, please follow: Bybit’s Communities and Social Media

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Blockchain Press Releases

Hata obtains full approval from the Securities Commission of Malaysia Launches 30% revenue sharing model on its USD crypto exchange

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  • Hata obtains full approval from the Securities Commission of Malaysia and launched its exchange
  • Support USD onramp and offramp
  • Rolled out affiliate programme, sharing 30% of its trading fee with users who refer others to trade on its Exchange
  • Zero trading fee across major pairs and opportunity to earn crypto airdrop

KUALA LUMPUR, Malaysia, July 19, 2024 /PRNewswire/ — Hata has officially secured full approval from the Securities Commission of Malaysia to launch its exchange. Having obtained full approval from the Labuan Financial Services Authority (a mid-shore jurisdiction in Malaysia) in June 2023, Hata is now the first and only dual-licensed exchange by both onshore and mid-shore regulators in Malaysia.

Filling the gap in Asia with USD onramp and offramp 

Hata operates a US Dollar cryptocurrency exchange, allowing users globally to deposit, trade and withdraw funds in US Dollars. Hata users can also swap US Dollars with USDT for free.

With the foreign exchange market in Asia Pacific recorded at $396 trillion annually[1], Hata aims to serve the large US Dollar foreign exchange market by providing traders and institutions a licensed platform to convert US Dollars into stablecoins to facilitate cross border payments and access cryptocurrency in the region.

“Institutions and high net worth individuals still rely heavily on US Dollars to settle cross border transactions in Asia. With institutional adoption into cryptocurrency on the rise, coupled with weakening local currencies in the region against US Dollar, we foresee users moving their monies into USD pegged stablecoins to conduct transactions.” says David Low, Chief Executive Officer of Hata.

Hata currently supports trading of more than 40 cryptocurrency pairs on its platform that are paired with USDT and US Dollar, with the goal of supporting more crypto products in the near future.

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30% Revenue Share on its Exchange

Hata (www.hata.io) has introduced an affiliate program. Any users who sign up on Hata can refer their family and friends to earn a reward. Hata provides a revenue share of 30% from the trading fees it earns to the affiliates who refer their network to trade on Hata’s exchange.

“This affiliate programme is designed to let users globally capitalise on their network to earn rewards. We hope that this provides an economic opportunity for our users to earn a side income with minimal effort,” says Darien Ng, Chief Revenue Officer of Hata.

Zero trading fees and free airdrop

To further incentivise early users, Hata has also rolled out zero fees for its major crypto pairs, including USD/USDT pair.

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Users who sign up from now until 31 October 2024 and trade on the exchange will be added to a waitlist. Users in the waitlist will have an opportunity to earn free airdrops in the near future.

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